CHICAGO (AP):

Medicine mix-ups, accidental overdoses and bad drug reactions harm roughly one out of 15 hospitalised children in the United States, according to the first scientific test of a new detection method.

That number is far higher than earlier estimates and bolsters concerns already heightened by well-publicised cases like the accidental drug overdose of actor Dennis Quaid's newborn twins last November.

"These data and the Dennis Quaid episode are telling us that ... these kinds of errors and experiencing harm as a result of your health care is much more common than people believe. It's very concerning," said Dr Charles Homer of the National Initiative for Children's Healthcare Quality. His group helped develop the detection tool used in the study.

Researchers found a rate of 11 drug-related harmful events for every 100 hospitalised children. That compares with an earlier estimate of two per 100 hospitalised children, based on traditional detection methods. The rate reflects the fact that some children experienced more than one drug-treatment mistake.

New monitoring method

The new estimate translates to 7.3 per cent of hospitalised children, or about 540,000 kids each year, a calculation based on government data.

Simply relying on hospital staffers to report such problems had found less than four per cent of the problems detected in the new study.

The new monitoring method developed for the study is a list of 15 'triggers' on young patients' charts that suggest possible drug-related harm. It includes use of specific antidotes for drug overdoses, suspicious side effects and certain lab tests.

By contrast, traditional methods include non-specific patient chart reviews and voluntary error reporting.

The researchers said their findings highlight the need for "aggressive, evidence-based prevention strategies to decrease the substantial risk for medication-related harm to our paediatric inpatient population".

The study is being released today in the April issue of the journal Pediatrics.